1995-1999 Issued Patents
The following U.S. patents were issued to University of Virginia inventors in the second half of the 1990s:
1995 Issued Patents
| Issue Date | Patent No. | Patent Title | Inventor(s) |
| 03/28/95 | 5,401,831 | Monoclonal Antibodies for Differentiating Pathogenic and Nonpathogenic E. Histolytica | William A. Petri Jr., Jonathan I. Ravdin |
| 04/11/95 | 5,405,748 | Diagnostic Methods For E. Histolytica | William A. Petri Jr., Jonathan I. Ravdin |
| 05/02/95 | 5,410,910 | Cryogenic Atomic Force Microscope | Jie Yang, Andrew P. Somlyo, Zhiferg Siao, Jianxun Mou |
| 05/30/95 | 5,420,024 | Process for Synthesis of Acylated HMG-CoA Reductase Inhibitors from a Lactone Diol Precursor Using Candida Cylindracea | Giorgio Carta, Michael J. Conder, John L. Gainer, Robert W. Stieber, Victor A. Vinci, Timothy W. Weber |
| 06/06/95 | 5,422,097 | Combined Antiviral and Antimediator Treatment of Common Colds | Jack M. Gwaltney Jr. |
| 06/13/95 | 5,424,297 | Adenosine Dextran Conjugates | Rafael Rubio, Eduardo Balcells, Jorge Suarez |
| 06/27/95 | 5,427,956 | Quantitative Analysis for Diabetic Condition Predictor | Alison S. Kennington, Joseph Larner |
| 06/27/95 | 5,428,066 | Method of Reducing Elevated Blood Sugar in Humans | Joseph Larner, Alison S. Kennington, Laura C. Huang |
| 07/25/95 | 5,436,157 | Human Intra-Acrosomal Sperm Antigen | John C. Herr, Richard M. Wright |
| 07/25/95 | 5,436,239 | Method of Treating Clostridium Difficile Colitis and Cholera | Richard L. Guerrant, Guodong Fang, Manasses C. Fonteles |
| 10/31/95 | 5,462,068 | Wrist Fixation Device for Elbow Stress Examination | Arie M. Rijke, Henry T. Goitz |
| 11/28/95 | 5,470,570 | Mammalian Primate Erythrocyte Bound Heteropolymerized Monoclonal Antibodies and Methods of Use Thereof | Ronald P. Taylor, William M. Sutherland, Craig Reist, Eleanor L. Wright, Donna J. Webb, Ronald Labuguen |
1996 Issued Patents
| Issue Date | Patent No. | Patent Title | Inventor(s) |
| 01/30/96 | 5,487,890 | Mammalian Primate Erythrocyte Bound Heteropolymerized Monoclonal Antibodies and Methods of Use Thereof | Ronald P. Taylor, William M. Sutherland, Craig Reist, Eleanor L. Wright, Donna J. Webb, Ronald Labuguen |
| 02/06/96 | 5,489,771 | LED Light Standard for Photo- and Videomicroscopy | James M. Beach, Brian R. Duling |
| 02/20/96 | 5,492,689 | Combined Virustatic Antimediator (COVAM) Treatment of Common Colds | Jack M. Gwaltney Jr. |
| 02/20/96 | 5,493,008 | Two Non-Contiguous Regions Contribute to Nidogen Binding to a Single EGF-like Motif of the Laminin Gamma 1 Chain | Jay W. Fox, Rupert Timpl |
| 04/02/96 | 5,503,986 | Detection of Urinary Tract Obstruction by Nerve Growth Factor Measurement in Urine | William D. Steers, Jeremy B. Tuttle |
| 04/23/96 | 5,510,260 | Prolactin Secreting Cell Line and Method of Obtaining the Same | Robert M. MacLeod, Margaret V. MacQueen, Ivan S. Login |
| 05/21/96 | 5,519,126 | Oligonucleotide N-alkylphosphoramidates | Sidney M. Hecht |
| 06/11/96 | 5,525,526 | Immunoassay for Inositols | Joel M. Linden, Thomas A. Piccariello, George Vandenhoff |
| 06/25/96 | 5,530,141 | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the Treatment of Disorders Mediated by Platelet Activating Factor or Products of 5-lipoxygenase | Tsung-ying Shen, David M. Goldstein |
| 07/09/96 | 5,534,314 | Directed Vapor Deposition of Electron Beam Evaporant | Haydn N.G. Wadley, James F. Groves |
| 07/09/96 | 5,535,231 | Optoelectronic Circuit Including Heterojunction Bipolar Transistor Laser and Photodetector | KwyRo Lee, Michael Shur, Stephen H. Jones |
| 07/16/96 | 5,536,822 | Gamma-Phosphate Linked Adenosine 5' Triphosphate Sepharose | Timothy A.J. Haystead |
| 10/01/96 | 5,561,111 | Stable Glutamine Derivatives for Oral and Intravenous Rehydration and Nutrition Therapy | Richard L. Guerrant, Timothy L. Macdonald, Aldo A.M. Lima, Nathan M. Thielman, Thomas Miller |
| 10/08/96 | 5,563,902 | Semiconductor Ridge Waveguide Laser with Lateral Current Injection | Jingming Xu, Michael Shur, Boris Gelmont |
| 11/05/96 | 5,571,690 | Method for the Cell-Free Synthesis of Proteins | Sidney M. Hecht |
| 11/05/96 | 5,571,952 | Electronic Viscometer | James J. Kauzlaurich |
| 12/10/96 | 5,583,010 | Nucleic Acid Molecule Encoding the Porcine Growth Hormone Receptor | William R. Baumbach, John R. Zysk, Michael O. Thorner, Bruce D. Gaylinn, Kevin R. Lynch, Jeffrey K. Harrison |
| 12/10/96 | 5,583,199 | Hemopoietic Growth-Regulatory Calmodulin-Binding Protein and Methods of Using the Same | Peter J. Quesenberry, G. Prem-Veer Reddy |
1997 Issued Patents
| Issue Date | Patent No. | Patent Title | Inventor(s) |
| 01/07/97 | 5,591,641 | Nucleic Acid Encoding the Growth Hormone Releasing Hormone Receptor | Michael O. Thorner, Bruce D. Gaylinn, John R. Zysk, Kevin R. Lynch, Jeffrey K. Harrison |
| 02/11/97 | 5,602,005 | Primate Intra-Acrosomal Sperm Antigen for Use in a Contraceptive Vaccine | John C. Herr, Richard M. Wright |
| 02/25/97 | 5,605,803 | Human Sperm Diagnostic | John C. Herr, Richard M. Wright |
| 03/18/97 | 5,612,470 | Nucleic Acid Encoding the Growth Hormone Releasing Hormone Receptor | Michael O. Thorner, Bruce D. Gaylinn, John R. Zysk, Kevin R. Lynch, Jeffrey K. Harrison |
| 05/06/97 | 5,626,691 | Bulk Nanocrystalline Titanium Alloys with High Strength | Dongjian Li, S. Joseph Poon, Gary J. Shiflet |
| 05/20/97 | 5,631,844 | Interactive Remote Sample Analysis System | Keith S. Margrey, Robin A. Felder, James C. Boyd, J. William Holman, John Savory |
| 06/03/97 | 5,635,540 | Stabilized Topical Pharmaceutical Preparations | Richard F. Edlich, Sherry Sutton, George T. Rodeheaver |
| 06/17/97 | 5,639,750 | Method of Inhibiting Secretory Effects Caused by Cholera | Richard L. Guerrant, Guodong D. Fang, Manasses C. Fonteles |
| 06/17/97 | 5,639,782 | Neolignan Derivatives as Platelet Activating Factor Receptor Antagonists and 5-Lipoxygenase Inhibitors | Tsung-ying Shen, David Goldstein, Diane M. Gingrich |
| 06/17/97 | 5,640,691 | Power Controller for RF Transmitter | Paul C. Davis, Brian K. Horton |
| 07/01/97 | 5,644,046 | Cloning of a Gene Encoding for the Growth Hormone Releasing Hormone Receptor | Michael O. Thorner, Bruce D. Gaylinn, Jeffrey K. Harrison, Kevin R. Lynch, John R. Zysk |
| 07/29/97 | 5,652,221 | Method of Treating Defective Glucose Metabolism Using Synthetic Insulin Substances | Joseph Larner, John Price, Thomas Piccariello, Laura C. Huang |
| 07/29/97 | RE35,576 | Method for Increasing the Corrosion Resistance of Aluminum and Aluminum Alloys | Rudolph G. Buchheit Jr., Glenn E. Stoner |
| 08/05/97 | 5,654,864 | Control Method for Magnetic Stereotaxis System | Rogers C. Ritter, Michael A. Lawson, Robert G. McNeil |
| 09/09/97 | 5,665,565 | Transfection of Enteric Parasites | William A. Petri Jr., R. Randolph Vines, Jay E. Purdy, Barbara J. Mann |
| 10/07/97 | 5,674,778 | Method of Manufacturing an Optoelectronic Circuit Including Heterojunction Bipolar Transistor, Laser and Photodetector | KwyRo Lee, Michael Shur, Stephen H. Jones |
| 11/11/97 | 5,686,310 | Method for Determination of the Amount of Either Phosphotyrosine or Phosphoserine in a Protein | Timothy A.J. Haystead, Timothy L. Macdonald, R. Patrick Fadden |
| 11/25/97 | 5,690,691 | Gastro-Intestinal Pacemaker Having Phased Multi-Point Stimulation | Jian Dez Chen, Richard W. McCallum, Ronald Williams, Robert Ross, Zhiyue Lin, Jonathan Tillack |
| 12/09/97 | 5,696,229 | Polypeptide with Laminin Cell Adhesion and Morphogenesis Activity | Gordon W. Laurie, Michelle L. Matter, Lanlin Chen |
| 12/16/97 | 5,698,549 | Method of Treating Hyperactive Voiding with Calcium Channel Blockers | William D. Steers, Jeremy B. Tuttle |
1998 Issued Patents
| Issue Date | Patent No. | Patent Title | Inventor(s) |
| 01/13/98 | 5,707,335 | Magnetic Stereotactic System and Treatment Delivery | Matthew A. Howard III, Marc Mayberg, M. Sean Grady, Rogers C. Ritter, George T. Gillies |
| 01/20/98 | 5,710,374 | Electronic Viscometer | Robert A. Ross, James J. Kauzlarich |
| 02/10/98 | 5,716,385 | Crural Diaphragm Pacemaker and Method for Treating Esophageal Reflux Disease | Ravinder K. Mittal, Robert Ross, Jiamnim Liu, Bruce Schirmer |
| 03/24/98 | 5,730,958 | Method of Treatment of Gastroesophageal Reflux Disease by Enhancement of Salivary Esophageal Protection Due to Mastication | Jerzy Sarosiek, Richard McCallum |
| 04/07/98 | 5,736,073 | Production of Nanometer Particles by Directed Vapor Deposition of Electron Beam Evaporant | Haydn N.G. Wadley, James F. Groves |
| 05/12/98 | 5,750,348 | Method for Detecting Insulin Resistance | Joseph Larner |
| 05/19/98 | 5,753,231 | Primate Intra-acrosomal Sperm Antigen for Use in a Contraceptive Vaccine | John C. Herr, Richard M. Wright |
| 06/23/98 | 5,770,201 | HA-2 Antigenic Peptide | Els A.J.M. Goulmy, Donald F. Hunt, Victor H. Engelhard |
| 06/30/98 | 5,772,993 | Osteocalcin Promoter-Based Toxic Gene Therapy for the Treatment of Calcified Tumors and Tissues | Leland W.K. Chung, Chinghai Kao, Robert A. Sikes, Song-Chu Ko, Jun Cheon |
| 07/14/98 | 5,779,694 | Magnetic Stereotactic System for Treatment Delivery | Matthew A. Howard III, Marc Mayberg, M. Sean Grady, Rogers C. Ritter, George T. Gillies |
| 07/21/98 | 5,783,829 | Energy and Position Sensitive Radiation Detectors | Richard Sealock, Oscar Rondon-Aramayo, Daniel Van Horn Bengis |
| 08/11/98 | 5,792,215 | Laser Integrated Targeting and Entry System and Method | David E. Martin, Phoebe A. Kaplan, Robert G. Dussault |
| 09/15/98 | 5,808,445 | Method for Monitoring Remaining Battery Capacity | James H. Aylor, Mark A. Lepsch |
| 09/29/98 | 5,814,066 | Reduction of Femoral Arterial Bleeding Post Catheterization Using Percutaneous Application of Fibrin Sealant | William D. Spotnitz |
| 10/06/98 | 5,817,679 | 7-Azabicyclo[2.2.1]-Heptane and -Heptene Derivatives as Cholinergic Receptor Ligands | Tsung-ying Shen, W. Dean Harman, Dao Fei Huang, Javier Gonzalez |
| 11/03/98 | 5,830,472 | Purified Sperm Surface Antigen, Monoclonal Antibody Therefor and Applications Therefor | John C. Herr, Alan B. Diekman, Elizabeth J. Norton, V. Anne Westbrook-Case |
| 11/03/98 | 5,830,588 | High Density Magnetic Recording Medium | David C. Douglass, Jean Pierre Bucher, Louis A. Bloomfield |
| 11/10/98 | 5,834,644 | Automatic Atomic Force Microscope with Piezotube Scanner | Zhifeng Shao, Jian Xun Mou, Gang Huang |
| 12/01/98 | 5,844,242 | Digital Mammography with a Mosaic of CCD Arrays | Antony Jalink Jr., James A. McAdoo |
| 12/22/98 | 5,852,187 | Molecular Cloning of the Ovine Pituitary Growth Hormone Releasing Hormone Receptor | Michael O. Thorner, Bruce D. Gaylinn, Reiko Horikawa, Charles E. Lyons Jr. |
| 12/29/98 | 5,854,006 | Gamma-Glutamyl Transpeptidase-Specific Antibody, Prodrugs for the Treatment of Gamma-Glutamyl Transpeptidase-Expressing Tumors, and Methods of Administration Thereof | Marie Hanigan, Timothy L. Macdonald |
| 12/29/98 | 5,854,081 | Stable Expression of Human A2B Adenosine Receptors, and Assays Employing the Same | Joel M. Linden, Heidi Taylor, Anna Robeva, Robin Woodard, Xiaowei Jin |
1999 Issued Patents
| Issue Date | Patent No. | Patent Title | Inventor(s) |
| 02/02/99 | 5,866,652 | Chromate-Free Protective Coatings | Harold E. Hager, Chris J. Johnson, Kay Y. Blohowiak, Chun M. Wong, John H. Jones, S. Ray Taylor, Robert L. Cook Jr. |
| 02/09/99 | 5,869,288 | Molecular Cloning of Cockroach Allergens, Amino Acid and Nucleotide Sequences Therefor and Recombinant Expression Thereof | Martin Chapman, L. Karla Arruda |
| 02/23/99 | 5,874,305 | Androgen-Repressed Metastatic Human Prostate Cancer Cell Line | Leland W.K. Chung, Haiyen E. Zhau, Shi-ming Chang |
| 03/02/99 | 5,877,180 | Method for Treating Inflammatory Diseases with A2A Adenosine Receptor Agonists | Joel M. Linden, Gail W. Sullivan |
| 03/09/99 | 5,879,679 | Antigen-Based Heteropolymers and Method for Treating Autoimmune Diseases Using the Same | Ronald P. Taylor, Polly J. Ferguson, Edward Martin Jr., William M. Sutherland, Craig J. Reist, Kirsten Greene, Cyd Johnson |
| 03/23/99 | 5,885,791 | Antifungal and Antibacterial Susceptibility Assay | Jim E. Cutler, Marcia H. Riesselman, Kevin C. Hazen |
| 03/23/99 | 5,886,532 | Nanometer Distance Regulation Using Electromechanical Power Dissipation | Julia W.P. Hsu, Mark Lee, Bascom S. Dearer Jr. |
| 04/06/99 | 5,891,634 | Transfection of Enteric Parasites | William A. Petri, Jr., R. Randolph Vines, Jay E. Purdy, Barbara J. Mann |
| 04/20/99 | 5,895,812 | Diagnostic for Sjogren’s Syndrome | Gordon W. Laurie, Rebecca A. Ogle, J. Douglas Glass |
| 04/20/99 | 5,895,843 | In Situ Sensor for Critical Corrosion Conditions in a Material | S. Ray Taylor, Patrick A. Cella |
| 05/11/99 | 5,902,787 | Chemically Modified a-macroglobulins, Methods of Making and Methods of Using the Same in Anti-Cytokine Therapy | Steven L. Gonias, Donna J. Webb |
| 07/27/99 | 5,929,095 | Method of Inhibiting Secretory Effects Caused by Cholera | Richard L. Guerrant, Guodong Fang, Manasses C. Fonteles |
| 08/24/99 | 5,942,390 | Method of Diagnosing Predisposition for Ulcerative Colitis in Jewish Population by Detection of Interleukin-1 Receptor Antagonist Polymorphism | Fabio Cominelli, Theresa Pizarro, Jerome I. Rotter, Huiying Yang |
| 10/05/99 | 5,962,239 | Method for Detection of Anti-HLA Antibodies | Peter I. Lobo |
| 10/12/99 | 5,966,424 | Radiation-Shielding, Interpolative-Sampling Technique for High Spatial Resolution Digital Radiography | Hong Liu |
| 10/26/99 | 5,973,114 | Isolation and Characterization of the Growth Hormone Releasing Hormone Receptor | Michael O. Thorner, Bruce D. Gaylinn, John R. Zysk, Cecil M. Eppler |
| 11/16/99 | 5,986,275 | Reusable Shielded Marker for Nuclear Medicine Imaging | Charles D. Teates |